Some species of this family have been used traditionally in south and central americas folk medicine for treating stomach disorders. Hydroxyproline, a serum biomarker candidate for gastric. Therefore, the present study was performed to evaluate the gastropreventive effect of aqueous ethanolic extract of c. For the first time, this study demonstrates that administration of zingerone at the doses of 100 and 200 mgkg decreases the lipid peroxidation in the stomach and attenuates the ethanolinduced gastric ulcer in the rat. Accordingly, this study was designed to examine gastroprotective action of pcg against ethanol induced gastric ulcer. Thirty two adult male rats were used in this study four groups and several parameters were determined to assess any degree of protection. Therapeutic effect of low molecular weight chitosan. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and omeprazole 20 mgkg and 62. Oral administration of ethanol extract of the rhizome ofpirorhiza kurroa at a dose of 20mgkg body weight, for 10 consecutive days, was found to enhance the rate of healing on indomethacininduced gastric ulcer in rats, compared to the ulcerated group. The gastro protective effects of cibotium barometz hair on. Evidencebased complementary and alternative medicine.
Prevention of hclethanol induced gastric mucosal injury. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence levels of the saline. A comparison study of metabolic analysis of gastric ulcer models induced by ethanol, stress, and aspirin kenichiro takeuchi1, maki ohishi2, keiko endo2, kenichi suzumura3, hitoshi naraoka1, takeji ohata1, jiro seki1, yoichi miyamae1, masashi honma4 and tomoyoshi soga2. Based on these results, a model for the pathogenesis of ethanolinduced gastric lesions is proposed.
Gastroprotective effect of gallic acid against ethanol. Ethanolinduced acute gastric ulceration eigu is widely studied. The possible involvements of lipid peroxidation, superoxide dismutase, and catalase were also investigated. The gastroprotective effect of ga could be partly related to the stimulations of. The first report of a role of ghrelin in gastroprotection was obtained in a model of ethanolinduced gastric ulcers in rats. The histological study supported the observed gastroprotective activity of exphy, showing a reduced inflammatory response. Ethanolinduced hyperemia was markedly reduced by lipoxygenaseselective inhibitors bw755c or nordihydroguaiaretic acid, or by the h 1antihistamine pyrilamine, but not by indomethacin, cimetidine, phentolamine, or methysergide. Cibotium barometz is a medical herb used traditionally in the malaysian peninsula for several ailments, including gastric ulcer. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n.
The present work was done to investigate the possible effects of nigella sativa oil nso on gastric secretion and ethanolinduced ulcer in rats. The gastroprotective effects of aqueous extract of h. Materials and methods animals adult male wistar albino rats weighing 170200 g were placed in polyethylene cages in groups of 6 and the. Relationship between ethanolinduced gastritis and gastric ulcer. The ulcers were measure using a graticule attached to a dissecting microscope.
Antiulcer and antioxidant activity of moringa oleifera. Wistar rats were pretreated with omeprazole 20mgkg body weight, 50mgkg, 100mgkg and 150mgkg per body weight of methanol and water extract separately. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. Evaluation of gastroprotective activity of myristica fragrans on. Pdf gastroprotective effect of zingerone on ethanol. To evaluate the antiulcer activity of caesalpinia pulcherrima on ethanol induced gastric lesion in albino rat. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. All the treatment doses of the extracts aepo and mepo and ranitidine suppressed the ulceration induced by ethanol. To evaluate the role of ala treatment on the healing of acetic acidinduced gastric ulcer, rats were given ala 35 mgkgday or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days early or 10 days late until they were decapitated.
The length mm and the width mm of each band was measured using planimeter 10 mm. The ulcer index and curative ratio were calculated for all the groups. The effect of znlscn on the ulcer area induced by hclethanol is shown in fig. Furthermore, exphy reversed the ethanolinduced increase in lipid peroxidation. Research paper ulcer prevention effect of 3,4,5tihydroxy.
Pdf ulceroprotective effect of methanol extract of. The aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside a ara against ethanol and aspirininduced gastric ulcer in mice. A zinc morpholine complex prevents hclethanolinduced. Diosmin protects against ethanolinduced gastric injury in. Ulcer can be induced by administration of hpylori, nonsteroidal antiinflammatory drugs. Limonia acidissima exhibited antiulcer activity against ethanol induced ulcer in rats.
Ketones have been reported to possess antiinflammatory, antioxidant and antiulcer activities. Protective effects of quercetin in ethanol induced gastric ulcer 41 lipoproteins, and other lipidcontaining structures under conditions of oxidative stress. Gastric ulcer gu is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Ethanolinduced gastric injury is a key experimental model commonly utilized for preclinical assessment of agents with potential antiulcer activity since ethanol has been regarded as a leading cause of gastric ulcer in humans 9, 10, 12. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced. After the treatment period, rats received oral administration of 1. Therefore, the fact that quercetin decreased lipid peroxidation might mean that quercetin has an antioxidant effect. The present study showed that zingerone has a protective effect on the ethanolinduced gastric ulcer, which may be due to its free radical scavenging activity. Pdf amelioration of ethanolinduced gastric ulcers in. Issn 24721646 of punicalagin against ethanolinduced.
Antiulcer activity of centella asiatica leaf extract against ethanolinduced gastric mucosal injury in rats. All animals were used according to the guidelines of the committee on care and use. Ulceration was induced by oral administration of absolute ethanol 1cm3kg body weight. Stomach ulcers were induced by oral ingestion of hydrochloride hcl ethanol or indomethacin. Mechanisms of gastroprotective effects of ethanolic leaf extract of. Gastroprotective effect of araloside a on ethanol and. Gallic acid ga showed protective effects against ethanolinduced gastric ulcer in rats. Studies on the mechanism of ethanolinduced gastric damage. The rats fasted for 24 hours but were allowed free access to drinking water up till 2 hours before the experiment. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal. Antiulcerogenic effect of cuphea ignea extract against. In this experiment, a novel biocompatible material, low molecular weight chitosan containing sepia ink lmcs was prepared for treating ethanolinduced gastric ulcer, which mainly based on two considerations. Gastric lesions were induced in rats by oral administration of ethanol 80% ethanol 1 ml, p.
The ulcer areas seen in the rats treated with znlscn were significantly lower p pdf is available to subscribers only. The chemical composition of plant extract, the unsaponi. Antiulcer activity of swietenia mahagoni leaf extract in ethanolinduced gastric mucosal damage in rats. Methods omeprazole omeprazole, as an antiulcer medicine and positive control was purchased from the university of malaya, medical center. Gastric ulcer in mice was induced by intragastric administration. These results were further supported by histopathological findings which revealed the curing effect of c. Gastroprotective activity of myristica fragrans was investigated by determination of gastric ph, free acidity, ulcer index score and on histopathological basis. Rats were fasted for 48 hours before administration of absolute ethanol 5.
Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by exphy pretreatment. The animals were sacrificed after 4 hr and functional indices of ulcer activity was studied in all rats and compared with that of nonulcer induced ones. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and. Phytochemical studies and antiulcer activity of limonia. Gastroprotective effect of zingerone on ethanolinduced. Omeprazole is a proton pump inhibitor drug that has being employed for the.
Oecd 2002 organization for economic cooperation and development guideline no. Pdf gastroprotective effects of betanin against ethanol. Chemical composition and protective role of pulicaria. Effects of zinc sulfate on ethanol and indomethacininduced ulceration and.
Effects of nigella sativa oil on gastric secretion and. Gastric ulcer appeared as elongated bands of hemorrhagic lesions in which the elongated lesions are the pathological features that related with ethanol induced ulcer. Protective effect of areca catechu leaf ethanol extract. Ethanolinduced gastric ulcer an overview sciencedirect topics. The aim of this study was assessment the antiulcer effects of c. Cuphea ignea is one of the herbal resources belonging to lythraceae family. Administration of ethanol causes gastric necrotic damage and subsequent inflammatory cell infiltration and reduces the secretion of bicarbonate, gastric mucus, and nitric oxide. Gastric ulcer was induced in overnight fasted rats that. Research article ethanolinduced gastric ulcer in male. Biochanin a gastroprotective effects in ethanolinduced. Ethanolinduced gastric ulcer is a common animal model to investigate the new antiulcer drugs.
Gastroprotective effect of zingerone on ethanolinduced gastric. This study aimed to evaluate acute toxicity and ulcer inhibitory effect of 2pentadecanone as a ketone bioactive compound against ethanolinduced gastric ulcer in sprague dawley rats. The experimental protocol and ethanolinduced gastric lesions method. Hericium erinaceus is a famous tonic in oriental medicine. Pdf gastroprotective effects of pistacia atlantica extract on. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. For this reason, many natural compounds have been explored as alternatives for these drugs. We performed histological as well as immunohistochemical examinations to explore the therapeutic. Antioxidant activity of ethanol extract of rhizome. The experimental mice were randomly divided into control, model, omeprazole 20 mgkg, orally and ara 10, 20 and 40 mgkg, orally.
The antiulcer activity of ethanolic extract of flowers of c aesalpinia pulcherrima cpfe was compared with standard drug famotidine. Ahvaz jundishapur university of medical sciences guidelines for. Alphalipoic acid improves acetic acidinduced gastric. During ethanol induced gastric oxidative stress, the accumulation of oxygenderived free radicals in ulcer areas could surpass the oxidation resistance of antioxidant defense system hence start intrinsic pathway of apoptosis and activate bax, a proapoptotic member of bcl2 family proteins.
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